Microsoft announced the immediate availability of the App-V 4.6 beta from Microsoft Connect.
One of the major improvements is that the sequencer now packages native 64-bit applications, and with this they seem to be the first in the market ! Off course this is a beta and the question is whether Microsoft will really be the first to release an RTM product that packages 64-bit apps.
Another big change is that this version of App-V supports X64 platforms (like Windows 7, Windows Server 2008 R2 etc.) as well as the X86 platform.
Check out more details here on the System Center Team Blog.